Polynucleotides and PRP Regenerative injections
Regenerative injections that signal your own cells to repair: for thin or crepey skin, under the eyes, texture and, after assessment, hair. Results build over a course.
Key facts
- Where
- CREAMÉ, 350 Al Wasl Road, Jumeirah 1, Dubai
- Session
- Usually numbing first, then small injections; PRP adds a blood draw
- Numbing
- Usually, numbing cream first
- Downtime
- Usually little; redness or swelling usually settles within a week
- Course
- 2–4 sessions, 2–4 weeks apart, then upkeep
What polynucleotides and PRP is for
Skin that has lost quality rather than volume: thin, crepey skin under the eyes, fine lines, rough texture, a tired surface. And, once the cause is known, some thinning hair.
Concerns it may help with
How polynucleotides and PRP works
Two regenerative injections that signal your own cells to repair, calming inflammation and waking collagen, rather than filling. Polynucleotides are purified DNA fragments from salmon or trout, placed as many tiny injections in the skin itself. PRP, platelet-rich plasma, is made fresh from a little of your own blood, spun to concentrate the platelets and the growth factors they carry, then injected into the skin or scalp.
A session, step by step
- We start with your concern, a look at your skin, photographs in the same light each time, and a check of your health, medicines and past injections in the area.
- The skin is cleansed and, usually, a numbing cream goes on.
- For PRP, a little blood is drawn from your arm and spun in a centrifuge to concentrate the platelets, fresh for each session and used straight away.
- The doctor places many small, shallow injections with a very fine needle across the area, in the skin or the scalp. On the face, sunscreen goes on before you leave.
What to expect
How it feels
Usually a numbing cream first, then small, quick injections with a very fine needle: a prick and a brief sting, usually well tolerated. For PRP, blood is drawn from your arm first, as for a blood test, and prepared while you wait.
Downtime
Usually little. Redness, swelling and tenderness are common, sometimes with a small bruise, and usually settle within a week. Most people are back at work the next day.
How many sessions
A course, not a single visit: usually two to four sessions, two to four weeks apart, with the change building gradually. How long it lasts hasn't been well measured, so most plans include upkeep every several months.
Who it may not suit
We go through your health and medicines first, because polynucleotides and PRP may not suit you, or may need to wait, if any of these apply:
- You are pregnant or breastfeeding.
- There is infection or inflamed skin in the area, or you have recently been unwell or had a fever.
- You are allergic to fish: polynucleotides come from salmon or trout.
- You have a bleeding disorder, a low platelet count or anaemia, or take blood thinners. Never stop a prescribed one without asking the doctor who prescribed it.
- You have taken anti-inflammatory painkillers such as ibuprofen in the last two days, steroid tablets in the last two weeks, or had a steroid injection in the area in the last month: we plan the date of PRP around them.
- You have cancer, especially of the blood or bone: this matters for PRP.
- You smoke: tobacco calls for extra care with PRP.
- You tend to form keloid or raised scars.
Risks and side effects
Common and short-lived: discomfort during the injections, then redness, swelling, tenderness, itching or a small bruise, usually settling within a week. PRP can also bring a mild headache, and rarely someone feels faint.
Results are gradual, partial and vary from person to person; how long they last is not well known. The polynucleotide studies are few, small and of low to moderate quality.
Rare, but serious: an injection can block a blood vessel. A review found ten published cases of sudden vision loss in one eye after PRP, mostly after injections between the brows or on the forehead and one after scalp PRP; in most, sight did not return. Unlike hyaluronic-acid filler, PRP cannot be dissolved. Over half were injected by non-doctors or people without adequate training. The polynucleotide studies reviewed reported no serious complication.
Infection: uncommon with sterile, single-use equipment. Because PRP is made from blood, infection control matters: a US public-health investigation linked HIV infections to PRP facials given without proper infection control.
Aftercare
- Plan a quiet first day: hard exercise, saunas and hot yoga can add to swelling and bruising.
- Sunscreen every day, reapplied when you are outside.
- Get urgent care, and call us, if your vision changes, pain grows instead of easing, or the skin turns pale, grey or blotchy.
- Message us if redness, swelling or a bruise hasn't settled within a week, or you notice signs of infection.
How pricing works
We don't publish prices. The cost depends on the treatment, the area and the number of sessions in your course, which we decide together at the consultation. You know the full plan and its cost before you start.
Our take
Polynucleotides and PRP work on the quality of skin, gently and over months. They don't fill, lift or relax.
The evidence is real but modest: mostly small studies, with gradual, partial improvements. We suggest them for thin, tired or delicate skin, often under the eyes, and we say so when the honest answer is filler, a lifting device, anti-wrinkle injections or nothing yet. A doctor leads your plan from the first conversation to the follow-up.
Questions people ask
What is a PRP facial: injections or microneedling?
It can be either. Platelet-rich plasma, made from a little of your own blood, is injected into the skin with a very fine needle, or spread over it straight after microneedling. At CREAMÉ a doctor injects it. In a review of PRP for ageing skin, injections brought modest improvements, most convincingly in texture.
Polynucleotides vs PRP: what are the benefits of each for the face?
Both aim to calm inflammation and wake collagen, for smoother, more elastic skin over time. Polynucleotides are purified fish DNA, a ready-made product with a set strength, often chosen for thin skin under the eyes. PRP is made from your own blood, so it varies with your platelets and how it is prepared, and it has been studied more.
Are polynucleotides and PRP worth it: do they work on the face, and how long do results last?
They can be, if you want a modest, gradual change. A review of PRP for ageing skin found improvements in texture and fine lines, usually by less than half. A review of polynucleotides found nine small studies of low to moderate quality, with gains in fine lines, texture and elasticity, not all clear-cut. How long results last hasn't been well measured, so plans include upkeep.
Are polynucleotides or a PRP facial good for under the eyes, and how many sessions does it take?
They can be, when the problem is thin, crepey skin or fine lines rather than a hollow or puffy bags. In an under-eye study of polynucleotides, without a comparison group, people rated the area better after the first session, best at three months after two sessions three weeks apart, and still better at six months. Around the eyes, PRP's strongest evidence is for dark circles from pigment.
Polynucleotides or a PRP facial vs filler or anti-wrinkle injections: which do I need?
It depends on the cause. Filler adds volume to a true hollow; anti-wrinkle injections relax the muscle behind a movement line. Polynucleotides and PRP do neither: they work gradually on the quality of thin, crepey or finely lined skin, and a plan can use more than one. A doctor looks at your face, at rest and moving, before suggesting any.
Polynucleotides vs skin boosters with hyaluronic acid: what's the difference?
Skin boosters supply; polynucleotides signal. Boosters are un-crosslinked hyaluronic acid with nutrients, placed to hydrate and feed the skin for glow and smoothness. Polynucleotides prompt your own cells to repair, calming inflammation and waking collagen, which suits skin too thin or delicate for filler, often under the eyes. A plan can include both.
PRP facial vs microneedling: can PRP or polynucleotides be combined with microneedling on the face?
They can be. Microneedling makes tiny channels that PRP or polynucleotides applied straight after can pass through. In a small split-face study of Sylfirm for lines around the eyes, the side given a polynucleotide serum after each session improved faster than the side given salt water. Our microneedling is Sylfirm X; whether to pair it with a regenerative is the doctor's call at your consultation.
What are the side effects and risks of a PRP facial or polynucleotides on the face?
Usually mild and short-lived: redness, swelling, tenderness, itching or a small bruise, usually settling within a week, and PRP can bring a mild headache. The rare, serious risk is an injection blocking a blood vessel: a review found ten published cases of vision loss after PRP, most after injections between the brows or on the forehead. The polynucleotide studies reviewed reported no serious complication.
What is the downtime and recovery time after a PRP facial or polynucleotides on the face, and what aftercare helps?
Usually little: most people are back at work the next day, with redness or swelling that usually settles within a week. Plan a quiet first day, as hard exercise, saunas and hot yoga can add to swelling and bruising, and wear sunscreen daily. Get urgent care, and call us, if your vision changes, pain grows or the skin turns pale or grey.
Can PRP or polynucleotides help with hair loss and hair growth, not just the face?
Sometimes, once the cause is known. PRP has been studied for pattern hair loss in men and women, alone or with other treatment, and several trials found more hairs per square centimetre, though methods vary widely; polynucleotides on the scalp have been studied far less. Hair starts with a trichology assessment with Dr. Olga Seredina, and PRP is suggested only if the cause suits it.
Are polynucleotides and a PRP facial done for men's faces too?
Yes, and the treatment is the same. The plan starts from your concern: thin skin under the eyes, fine lines, rough texture or, after a trichology assessment, thinning hair. Most people in the published studies were women, so there is less evidence specific to men; in one under-eye study of polynucleotides, about a quarter were men.
Can I have polynucleotides or PRP on my face during pregnancy?
No, we wait. Studies of these treatments usually leave out pregnant and breastfeeding women, so there is little or no evidence on what they do then. We plan them for after you have finished breastfeeding, and the doctor sets the timing with you.
Where can I get polynucleotides or PRP in Dubai, and how do I choose a clinic?
At CREAMÉ's Aesthetic Clinic, 350 Al Wasl Road, Jumeirah 1, a doctor assesses you and does the treatment. Wherever you go, check that a licensed doctor assesses and treats you in a licensed medical setting, with sterile, single-use equipment: a review found that over half the published cases of vision loss after PRP were injected by non-doctors or people without adequate training. Then look for an assessment before any plan, honesty about the modest evidence and the risks, and a follow-up visit.
How much do polynucleotides and PRP cost per session in Dubai?
We don't publish prices. The cost depends on the treatment, the area, such as under the eyes, the whole face or the scalp, and the number of sessions, which we set together at the consultation. You know the full plan and its cost before you start.
Sources
- Lampridou S, Bassett S, Cavallini M, Christopoulos G. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025;24(2):e16721.
- Ziade G, Keyrouz E, El Maalouf J, et al. Prospective observational study of polynucleotide injections for periorbital rhytides. J Cosmet Dermatol. 2026;25(2):e70736.
- Yogya Y, Wanitphakdeedecha R, Wongdama S, et al. Efficacy and safety of using noninsulated microneedle radiofrequency alone versus in combination with polynucleotides for treatment of periorbital wrinkles. Dermatol Ther (Heidelb). 2022;12(5):1133–1145.
- Maisel-Campbell AL, Ismail A, Reynolds KA, et al. A systematic review of the safety and effectiveness of platelet-rich plasma (PRP) for skin aging. Arch Dermatol Res. 2020;312(5):301–315.
- Sollitto CF, Narduzzi M, Wolinsky C. A systematic review of platelet-rich plasma versus platelet-rich fibrin for periorbital rejuvenation. J Cosmet Dermatol. 2025;24(11):e70524.
- Paichitrojjana A, Paichitrojjana A. Platelet rich plasma and its use in hair regrowth: a review. Drug Des Devel Ther. 2022;16:635–645.
- Ebrahimzade M, Nazari S, Pourani MR, et al. Ophthalmic vascular occlusion and blindness after platelet-rich plasma injections: a systematic review. J Cosmet Dermatol. 2026;25(6):e70918.
- Stadelman-Behar AM, Gehre MN, Atallah L, et al. Investigation of presumptive HIV transmission associated with receipt of platelet-rich plasma microneedling facials at a spa among former spa clients — New Mexico, 2018–2023. MMWR Morb Mortal Wkly Rep. 2024;73(16):372–376.
Updated 27 October 2026